ピロリ菌検査の感度と特異度はどのくらいですか？（日本ヘリコバクター学会ガイドライン2015） | 2017年12月11日

以前の記事の続きです。ピロリ菌感染診断法における各検査の感度・特異度を以下の表にまとめました。やはり尿素呼気検査の感度と特異度は高いですね。

表１. ピロリ菌感染診断法の感度・特異度
⌘ 参考文献

表１. ピロリ菌感染診断法の感度・特異度

診断法	感度（%）	特異度（%）
迅速ウレアーゼ試験除菌前¹⁾ 除菌後²⁾	85～9561～100	95～10091～100
鏡検法除菌前　　　　　HE 染色^3,4) 　　　　　　ギムザ染色³⁾	92～9988	89～10098
培養法⁵⁾	68 ～ 98	100
尿素呼気試験 ^6-9)	95～98	95～97
抗体測定法除菌前　　　　　血清抗体 ^10,11) 　　　　　尿中抗体^10,11)	88～10085～96	50～10079～90
便中抗原測定法　　　　　　除菌前¹²⁾ 　　除菌後^13-15)	96～10075～90	97～10096～100

（日本ヘリコバクター学会ガイドライン2015から引用）

⌘ 参考文献

Ricci C et al.Diagnosis of Helicobacter pylori: invasive and non-invasive tests. Best Pract Res Clin Gastroenterol. 2007; 21(2): 299-313. [PMID:17382278]
Vaira D et al.How useful is the rapid urease test for evaluating the success of Helicobacter pylori eradication therapy? Nat Clin Pract Gastroenterol Hepatol. 2007 Nov; 4(11): 600-1. [PMID: 17925801]
Laine L et al. Prospective comparison of H&E, Giemsa, and Genta stains for the diagnosis of Helicobacter pylori. Gastrointest Endosc. 1997 Jun; 45(6): 463-7. [PMID: 9199901]
MacOni G et al.Is routine histological evaluation an accurate test for Helicobacter pylori infection? Aliment Pharmacol Ther. 1999 Mar; 13(3): 327-31. [PMID:10102966]
Cutler AF. Diagnostic tests for Helicobacter pylori infection. Gastroenterologist. 1997 Sep; 5(3): 202-12. [PMID: 9298375]
Gisbert JP et al. Review article: 13C-urea breath test in the diagnosis of Helicobacter pylori infection — a critical review. Aliment Pharmacol Ther. 2004 Nov 15; 20(10): 1001-17. [PMID: 15569102]
Kato M et al.Clinical studies of 13C-urea breath test in Japan. J Gastroenterol. 1998; 33 Suppl 10: 36-9. [PMID:9840015]
Ohara S et al.Studies of 13C-urea breath test for diagnosis of Helicobacter pylori infection in Japan. J Gastroenterol. 1998 Feb; 33(1): 6-13. [PMID: 9497214]
Ohara S et al. The UBiT-100 ¹³CO₂ infrared analyzer: comparison between infrared spectrometric analysis and mass spectrometric analysis. Helicobacter. 1998 Mar; 3(1): 49-53. [PMID: 9546118]
Kato M et al. Clinical usefulness of urine-based enzyme-linked immunosorbent assay for detection of antibody to Helicobacter pylori: a collaborative study in nine medical institutions in Japan. Helicobacter 2000; 5: 109-119. [PMID: 10849061]
Murakami K et al. An evaluation of the performance of a novel stick-type kit for rapid detection of Helicobacter pylori antibodies in urine. Clin Lab 2011; 57: 481-487. [PMID: 21888011]
Sato M et al. Characterization and usefulness of stool antigen tests using a monoclonal antibody to Helicobacter pylori catalase. J Gastroenterol Hepatol 2012; 27 Suppl 3: 23-28. [PMID: 22486867]
Chey WD. Proton pump inhibitors and the urea breath test: how long is long enough? Am J Gastroenterol 1997; 92: 720-721. [PMID:9128344]
Shimoyama T et al. Applicability of a rapid stool 17 antigen test, using monoclonal antibody to catalase, for the management of Helicobacter pylori infection. J Gastroenterol 2011; 46: 487-491. [PMID: 21264478]
Shimoyama T et al. Comparison of monoclonal antibody-based stool antigen tests to determine the results of Helicobacter pylori eradication therapy. Scand J Gastroenterol 2010; 45: 1431-1434. [PMID: 20695725]